SUTD – Chao Wang, Weijie Chi, Davin Tan, and Xiaogang Liu
Dalian Institute of Chemical Physics – Qinglong Qiao and Zhaochao Xu
The SUTD-led study leverages systematic design and molecular engineering to develop brighter, more sensitive fluorophores used in detection probes and imaging labels.
During twisted intramolecular charge transfer (TICT) – a photophysical process that occurs in many fluorophores – fluorescence gets extinguished. The donor and acceptor fragments of the fluorophore will twist to a nearly perpendicular conformation after photoexcitation, resulting in complete charge separation while transforming into a dark state.
You can find more details at https://sutd.edu.sg/Research/Research-News/2021/11/Sparking-new-insights-into-dye-chemistry